PARTNERSHIP POLICIES: A CONVERSATION WITH JENNIFER SIEBEL NEWSOM, THE FIRST PARTNER OF CALIFORNIA


Evidence for long-term association of virion-delivered HBV core protein with cccDNA independently of viral protein production

Background & Aims: HBV persists in the nucleus of infected hepatocytes as a covalently closed circular DNA (cccDNA) episome that constitutes the template for viral RNA and protein synthesis.Both HBx and HBc (core) viral proteins associate with cccDNA but, while HBx is required for viral transcription, the role of HBc is still unclear.The aim of

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Developing a Bayesian network model for understanding river catchment resilience under future change scenarios

The resilience of river catchments and the vital socio-ecological services they provide are threatened by the cumulative impacts of future climatic and socio-economic change.Stakeholders who manage freshwaters require tools for increasing IEC Power Cords their understanding of catchment system resilience when making strategic decisions.However, unr

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Normalization of the tumor microenvironment by harnessing vascular and immune modulation to achieve enhanced cancer therapy

Abstract Solid Brow Serum tumors are complex entities that actively shape their microenvironment to create a supportive environment for their own growth.Angiogenesis and immune suppression are two key characteristics of this tumor microenvironment.Despite attempts to deplete tumor blood vessels using antiangiogenic drugs, extensive vessel pruning h

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